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Lalezari S, Lee CJ, Borovikova AA, Banyard DA, Paydar KZ, Wirth GA, Widgerow AD, et al.
International wound journal. Date of publication 2017 Aug 1;volume 14(4):649-657.
1. Int Wound J. 2017 Aug;14(4):649-657. doi: 10.1111/iwj.12658. Epub 2016 Sep 29. Deconstructing negative pressure wound therapy. Lalezari S(1), Lee CJ(1), Borovikova AA(1), Banyard DA(1), Paydar KZ(1), Wirth GA(1), Widgerow AD(1). Author information: (1)Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, CA, USA. Since its introduction 20 years ago for the treatment of chronic wounds, negative pressure wound therapy use has expanded to a variety of other wound types. Various mechanisms of action for its efficacy in wound healing have been postulated, but no unifying theory exists. Proposed mechanisms include induction of perfusion changes, microdeformation, macrodeformation, exudate control and decreasing the bacterial load in the wound. We surmise that these different mechanisms have varying levels of dominance in each wound type. Specifically, negative pressure wound therapy is beneficial to acute open wounds because it induces perfusion changes and formation of granulation tissue. Post-surgical incisional wounds are positively affected by perfusion changes and exudate control. In the context of chronic wounds, negative pressure wound therapy removes harmful and corrosive substances within the wounds to affect healing. When skin grafts and dermal substitutes are used to close a wound, negative pressure wound therapy is effective in promoting granulation tissue formation, controlling exudate and decreasing the bacterial load in the wound. In this review, we elucidate some of the mechanisms behind the positive wound healing effects of negative pressure wound therapy, providing possible explanations for these effects in different wound types. © 2016 Medicalhelplines.com Inc and John Wiley & Sons Ltd. DOI: 10.1111/iwj.12658 PMID: 27681204 [Indexed for MEDLINE]
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Negative Pressure Wound Therapy