Ozcan C, Ergün O, Celik A, Cördük N, Ozok G, et al.
Burns : journal of the International Society for Burn Injuries. Date of publication 2002 Dec 1;volume 28(8):791-4.
1. Burns. 2002 Dec;28(8):791-4.
Enzymatic debridement of burn wound with collagenase in children with
partial-thickness burns.
Ozcan C(1), Ergün O, Celik A, Cördük N, Ozok G.
Author information:
(1)Ege University Faculty of Medicine, Department of Pediatric Surgery, Pediatric
Burns Unit, 35100 Bornova, Izmir, Turkey. cozcan@med.ege.edu.tr
Seventy-eight pediatric burn patients treated by enzymatic debridement with
collagenase clostridiopeptidase A (CCA), were compared to 41 patients those burn
wounds were excised surgically. Patients whose burn wounds were initially
assessed as partial-thickness at admission were enrolled in the study. Total
removal of eschar was achieved in 49 of 78 (62.8%) patients by CCA only (group
D). In 29 patients (37.2%), therapy with CCA was ceased because of the
development of burn wound infection or a manifest need for grafting of the wound,
therefore, these patients underwent tangential wound excision (group DS). The
records of 41 patients, treated by early tangential excision, having similar burn
wounds by extent and depth with groups D and DS were used as controls (group S).
There was no significant difference between the time to achieve a clean wound bed
in groups D, DS and S (mean 7.8, 8, and 7 days, respectively, P>0.05). In group
D, none of the patients required blood transfusion, except one. Patients in group
DS were found to have fewer excisions (mean 1.1) when compared to those in group
S (mean 1.5, P<0.05). The shortest hospital stay was found in group D (12.5 days,
P<0.01). In conclusion, the use of CCA, provided a short hospital stay, reduced
the overall need for surgery and blood transfusions in patients with
partial-thickness burns. Thus, CCA should be considered as an initial treatment
of choice for removal of eschar in children, having a partial-thickness burn
wound without infection.
PMID: 12464480 [Indexed for MEDLINE]
