Hampson NB, Holm JR, Wreford-Brown CE, Feldmeier J, et al.
Cancer. Date of publication 2012 Aug 1;volume 118(15):3860-8.
1. Cancer. 2012 Aug 1;118(15):3860-8. doi: 10.1002/cncr.26637. Epub 2011 Dec 2.
Prospective assessment of outcomes in 411 patients treated with hyperbaric oxygen
for chronic radiation tissue injury.
Hampson NB(1), Holm JR, Wreford-Brown CE, Feldmeier J.
Author information:
(1)Center for Hyperbaric Medicine, Virginia Mason Medical Center, 1100 Ninth
Avenue, Seattle, WA 98101, USA. neil.hampson@vmmc.org
BACKGROUND: Although hyperbaric oxygen is used to treat chronic radiation tissue
injury, clinical evidence supporting its efficacy has been limited to date. The
authors report prospectively collected patient outcomes from a single center's
large experience using hyperbaric oxygen to treat chronic radiation injury.
METHODS: Since 2002, patient outcomes at the conclusion of a course of hyperbaric
oxygen treatment for chronic radiation tissue injury at Virginia Mason Medical
Center in Seattle have been graded by a board-certified hyperbaric physician and
prospectively recorded. From 2002 to 2010, a total of 525 patients received
treatment for 1 of 6 forms of radionecrosis analyzed. After excluding 114
patients for incomplete records or treatment courses or for previous receipt of
hyperbaric oxygen therapy, records of 411 patients were retrospectively reviewed
in 2010, and outcomes were regraded by a second board-certified physician. A
positive clinical response was defined as an outcome graded as either "resolved"
(90%-100% improved) or "significantly improved" (50%-89% improved).
RESULTS: A positive outcome from hyperbaric treatment occurred in 94% of patients
with osteoradionecrosis of the jaw (n = 43), 76% of patients with cutaneous
radionecrosis that caused open wounds (n = 58), 82% of patients with laryngeal
radionecrosis (n = 27), 89% of patients with radiation cystitis (n = 44), 63% of
patients with gastrointestinal radionecrosis (n = 73), and 100% of patients who
were treated in conjunction with oral surgery in a previously irradiated jaw (n =
166).
CONCLUSIONS: The outcomes of 411 patients collected prospectively over 8 years
strongly supported the efficacy of hyperbaric oxygen treatment for the 6
conditions evaluated. The response rates previously reported in numerous small
series were supported by the responses achieved in this large, single-center
experience.
Copyright © 2011 American Cancer Society.
DOI: 10.1002/cncr.26637
PMID: 22139864 [Indexed for MEDLINE]
