Feldmeier JJ, Heimbach RD, Davolt DA, McDonough MJ, Stegmann BJ, Sheffield PJ, et al.
Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, In.... Date of publication 2000 Apr 1;volume 27(1):15-9.
1. Undersea Hyperb Med. 2000 Spring;27(1):15-9.
Hyperbaric oxygen in the treatment of delayed radiation injuries of the
extremities.
Feldmeier JJ(1), Heimbach RD, Davolt DA, McDonough MJ, Stegmann BJ, Sheffield PJ.
Author information:
(1)Medical College of Ohio, Toledo, USA.
Hyperbaric oxygen (HBO2) is used as an adjunct in the treatment of radiation
injury at many sites, including the mandible, larynx, chest wall, bladder, and
rectum. In these disorders, HBO2 is effective in stimulating neovascularization
and reducing fibrosis. No previous publications report the application of HBO2 to
radiation injuries of the extremities. From 1979 until 1997, 17 patients were
treated at the Southwest Texas Methodist and Nix Hospitals for nonhealing
necrotic wounds of the extremities within previously irradiated fields. All but
one wound involved a lower extremity. Most of the patients had been irradiated
for soft tissue sarcomas or skin cancers. The rest were irradiated for a variety
of malignancies. HBO2 was delivered in a multiplace chamber at 2.4 atm abs daily
for 90 min of 100% oxygen at pressure. This report is a retrospective,
uncontrolled review of these patients. Eleven patients (65%) healed completely
whereas five (29%) failed to heal and one (6%) was lost to follow-up. Three (60%)
of those who failed were found to have local or distant recurrence of their tumor
early in their course of hyperbaric treatment and were discontinued from therapy
at that time. When last seen in the clinic, the wound of the patient who was lost
to follow-up was improved but not completely healed. Four of those who failed
(including the two with local tumor recurrence) required amputation. If we
exclude those with active cancer and the patient lost to follow-up, the success
rate was 11 of 13 or 85%. HBO2 was applied successfully with complete wound
healing and the avoidance of amputation in a majority of these patients. The
consequences of failure in patients suffering from radiation necrosis of the
extremities (some complicated by the presence of tumor) are significant, with 80%
of the five failures requiring amputation. In radiation injuries of the
extremities as in delayed radiation injury at other sites, HBO2 is a useful
adjunct and should be part of the overall management.
PMID: 10813435 [Indexed for MEDLINE]
