Feldmeier JJ, Heimbach RD, Davolt DA, Court WS, Stegmann BJ, Sheffield PJ, et al.
Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, In.... Date of publication 1995 Dec 1;volume 22(4):383-93.
1. Undersea Hyperb Med. 1995 Dec;22(4):383-93.
Hyperbaric oxygen as an adjunctive treatment for delayed radiation injury of the
chest wall: a retrospective review of twenty-three cases.
Feldmeier JJ(1), Heimbach RD, Davolt DA, Court WS, Stegmann BJ, Sheffield PJ.
Author information:
(1)Department of Radiation Oncology, Grace Hospital, Detroit, Michigan, USA.
Since 1979, 23 cases of radiation-induced chest wall necrosis have been treated
in the Hyperbaric Medicine Departments of Southwest Texas Methodist Hospital and
the Nix Hospital, San Antonio, Texas. Eight cases involved soft tissue only. Six
of eight (75%) patients with soft tissue involvement healed without requiring
surgical debridement, although four patients (50%) did have flaps or grafts.
Fifteen patients had bony and soft tissue necrosis. Eight of these patients (53%)
resolved with adjunctive hyperbaric oxygen (HBO), but all required aggressive
surgical debridement including skeletal resection. Four (27%) had reconstructive
flaps as well. Six patients (40%) with bony necrosis who had either no or
incomplete debridement failed to heal. Three patients (13%)(two soft tissue and
one bony) were found to have residual tumor during HBO and were discontinued from
treatment. HBO is an effective adjunctive therapy for soft tissue chest-wall,
radiation-induced necrosis, but must be coupled with appropriate debridement to
include surgical removal of all necrotic bone to ensure a successful outcome of
bony plus soft tissue necrosis.
PMID: 8574126 [Indexed for MEDLINE]
