Borab Z, Mirmanesh MD, Gantz M, Cusano A, Pu LL, et al.
Journal of plastic, reconstructive & aesthetic surgery : JPRAS. Date of publication 2017 Apr 1;volume 70(4):529-538.
1. J Plast Reconstr Aesthet Surg. 2017 Apr;70(4):529-538. doi:
10.1016/j.bjps.2016.11.024. Epub 2016 Dec 14.
Systematic review of hyperbaric oxygen therapy for the treatment of
radiation-induced skin necrosis.
Borab Z(1), Mirmanesh MD(2), Gantz M(1), Cusano A(3), Pu LL(3).
Author information:
(1)Drexel University College of Medicine, Philadelphia, PA, USA.
(2)Division of Plastic Surgery, University of California Davis, Sacramento, CA,
USA. Electronic address: mmirmanesh@ucdavis.edu.
(3)Division of Plastic Surgery, University of California Davis, Sacramento, CA,
USA.
Every year, 1.2 million cancer patients receive radiation therapy in the United
States. Late radiation tissue injury occurs in an estimated 5-15% of these
patients. Tissue injury can include skin necrosis, which can lead to chronic
nonhealing wounds. Despite many treatments available to help heal skin necrosis
such as hyperbaric oxygen therapy, no clinical guidelines exist and evidence is
lacking. The purpose of this review is to identify and comprehensively summarize
studies published to date to evaluate the effectiveness of hyperbaric oxygen
therapy for the treatment of radiation-induced skin necrosis. Adhering to PRISMA
guidelines, a systematic review of currently published articles was performed,
evaluating the use of hyperbaric oxygen to treat skin necrosis. Eight articles
were identified, including one observational cohort, five case series, and two
case reports. The articles describe changes in symptoms and alteration in wound
healing of radiation-induced skin necrosis after treatment with hyperbaric oxygen
therapy. Hyperbaric oxygen therapy is a safe intervention with promising
outcomes; however, additional evidence is needed to endorse its application as a
relevant therapy in the treatment of radiation-induced skin necrosis.
Copyright © 2016 British Association of Plastic, Reconstructive and Aesthetic
Surgeons. Published by Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.bjps.2016.11.024
PMID: 28081957 [Indexed for MEDLINE]
