Dieleman FJ, Phan TTT, van den Hoogen FJA, Kaanders JHAM, Merkx MAW, et al.
International journal of oral and maxillofacial surgery. Date of publication 2017 Apr 1;volume 46(4):428-433.
1. Int J Oral Maxillofac Surg. 2017 Apr;46(4):428-433. doi:
10.1016/j.ijom.2016.12.004. Epub 2016 Dec 30.
The efficacy of hyperbaric oxygen therapy related to the clinical stage of
osteoradionecrosis of the mandible.
Dieleman FJ(1), Phan TTT(2), van den Hoogen FJA(3), Kaanders JHAM(4), Merkx
MAW(5).
Author information:
(1)Department of Head and Neck Surgical Oncology, UMC Utrecht Cancer Centre,
University Medical Center Utrecht, The Netherlands; Department of Oral and
Maxillofacial Surgery, Radboud University Medical Centre Nijmegen, The
Netherlands.
(2)Department of Oral and Maxillofacial Surgery, Radboud University Medical
Centre Nijmegen, The Netherlands.
(3)Department of Otorhinolaryngology and Head and Neck surgery, Radboud
University Medical Centre Nijmegen, The Netherlands.
(4)Department of Radiation Oncology, Radboud University Medical Centre Nijmegen,
The Netherlands.
(5)Department of Oral and Maxillofacial Surgery, Radboud University Medical
Centre Nijmegen, The Netherlands. Electronic address: thijs.merkx@radboudumc.nl.
This study aimed to evaluate the success of hyperbaric oxygen therapy (HBOT) and
surgery in the treatment of mandibular osteoradionecrosis (ORN) in relation to
the extent of the ORN. Twenty-seven patients with ORN were identified from a
total of 509 patients with a history of primary oral or base of the tongue
cancer; these patients had been treated with radiation therapy with curative
intent between 1992 and 2006, with a radiation dose to the mandible of ≥50Gy. The
ORN was staged according to the classification of Notani et al. The time from
completion of radiation therapy to the development of ORN varied (median 3
years). Forty HBOT sessions were offered. After HBOT alone, 3 of 11 stage I
lesions, 0 of 8 stage II lesions, and 0 of 8 stage III lesions had healed
(P=0.0018). An absolute incidence of 5.3% ORN was found in this population. Of
all sites irradiated in this study, the floor of the mouth was most associated
with ORN (8.6%), whereas the cheek was least associated (0%). Based on the
results of this study, HBOT can be recommended for stage I and II ORN and for
selected cases of stage III ORN.
Copyright © 2017 International Association of Oral and Maxillofacial Surgeons.
Published by Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.ijom.2016.12.004
PMID: 28043745
