Author(s) Authors, CPG; Huang, Enoch T; Mansouri, Jaleh; Hassan Murad, M; Joseph, Warren S; Strauss, Michael B; Tettelbach, William; Worth, Eugene R; Feldmeier, John; LeDez, Ken; Jeannie Le, Phi-Nga; ..., et al.

Journal UHM 2015. Date of publication 2017 Oct 7;volume 42(3):.

Abstract BACkgRound: The role of hyperbaric oxygen (HBO 2) for the treatment of diabetic foot ulcers (DFUs) has been examined in the medical literature for decades. There are more systematic reviews of the HBO 2 / DFU literature than there have been randomized controlled trials (RCTs), but none of these reviews has resulted in a clinical practice guideline (CPG) that clinicians, patients and policy-makers can use to guide decision-making in everyday practice. MeThodS: The Undersea and Hyperbaric Medical Society (UHMS), following the methodology of the Grading of Recommendations Assessment, Development and Evalua-tion (GRADE) Working Group, undertook this systematic review of the HBO 2 literature in order to rate the quality of evidence and generate practice recommendations for the treatment of DFUs. We selected four clinical questions for review regarding the role of HBO 2 in the treatment of DFUs and analyzed the literature using patient populations based on Wagner wound classification and age of the wound (i.e., acute post-operative wound vs. non-healing wound of 30 or more days). Major amputation and incom-plete healing were selected as critical outcomes of interest.

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