Author(s) Hanley, Mary; Cooper, Jeffrey, et al.

Journal StatPearls. Date of publication 2017 Jan 1;volume ():.

Abstract Osteomyelitis is infection of the bone or marrow due to bacteria or mycobacteria.  It is difficult to treat due to the relative paucity of blood vessels in bone and the fact that many antimicrobials do not penetrate bone well. Refractory osteomyelitis is a chronic osteomyelitis that does not respond or that returns after appropriate treatment. Patients presenting with osteomyelitis to the spine, skull, or sternum have a high risk for morbidity and mortality from this infection.  The standard treatments for chronic and refractory osteomyelitis consists of surgical debridement and culture directed antibiotics. Hyperbaric oxygen treatments can be considered an American Heart Association (AHA) Class II recommendation for the treatment of chronic, refractory osteomyelitis.  In patients with Wagner grade 3 or 4 diabetic foot ulcers (DFU) with osteomyelitis, adjunctive hyperbaric oxygen therapy is an AHA Class I intervention. Copyright © 2017, StatPearls Publishing LLC.

Source ID (e.g. PMID): 28613536