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Collagenase SANTYL* Ointment

Santyl Collagenase is an enzymatic debrider. CLAIMED BENEFITS: It actively and selectively removes necrotic tissue without harming granulation tissue. INTENDED USE: indicated for debriding chronic dermal ulcers and severely burned areas.

Product Information

Enzymatic debridement relies on the use of enzymes to remove dead tissue. Enzymatic debridement is a technique that removes dead tissue more slowly than debridement with a scalpel (sharp or surgical debridement). The technique is often used in patients who cannot tolerate sharp debridement or to complement sharp debridement. This technique should not be used on wounds with exposed deep tissues, facial burns, or any wound requiring more rapid debridement. Collagenase: Common brand name: Santyl

Pricing and Suppliers

Is it covered by Medicare Part B?

Debridement is a medical procedure covered by Medicare as long as requirements are met. Among requirements, the wound needs to have devitalized, fibrotic, nonviable tissue, infection, necrosis, foreign matter, and the debridement method used needs to be recognized by Medicare as a proven method, supported by valid scientific literature. Enzymatic debridement is one of these methods.

How can I purchase this product?

Under Medicare, the cost of the enzymatic debridement agent is included in the debridement service. In other cases in which you need to purchase it separately, you will need a prescription from your provider to purchase it from a pharmacy or manufacturers. 

The table below shows highest and lowest Medicare pricing across the country
DescriptionMedicare DME co-payment Min / Max
Unclassified biologics $0.00 / $0.00
Estimated out-of-pocket cost:

If your insurance does not cover this product, you can purchase it directly from any store. A list of online stores and prices is provided below for your convenience. For updated prices, find it on the internet at

Other Stores

* Indicates whether store accepts Medicare or commercial insurance, but may not apply to this specific product. See coding, coverage and reimubursement for more information.
The information on this handout is for your convenience and educational purposes only. All product claims and specifications are those of the product suppliers. It does not constitute medical advice or a guarantee for reimbursement. Prices may have changed and suppliers may not have product in stock. Please confirm accuracy and appropriateness of information with insurance carrier and product supplier. Clinician and WoundReference assume no liability for inaccuracies or misstatements about products and insurance coverage.