Print Handout

Unbiased information for educational purposes only. WoundReference does not produce, market, advertise, re-sell or distribute healthcare goods or services consumed by, or used on patients. For information about specific products, please contact the manufacturer directly.

Technology and Product Assessment:

Apligraf®, Skin Substitute Per Square Centimeter

Product Type: Composite matrix

Other related brands

Organogenesis | |

HCPCS : Q4101 (Medicare DME co-payment per billable unit min / max: $0.00 / $0.00)

Apligraf is a living, cell-based, bilayered skin substitute.
INTENDED USE: For treating chronic venous leg ulcers and diabetic foot ulcers.
CLAIMED FEATURES: The lower layer contains bovine type 1 collagen and human fibroblasts to form a dermis-like structure that produces additional matrix proteins. Human keratinocytes form an epidermal layer to replicate the structure of the human epidermis. The human keratinocytes and fibroblasts are derived from neonatal foreskins. Apligraf stimulates the patient's own cells to regenerate tissue and heal the wound through mechanisms that may include the secretion of growth factors, cytokines, and matrix proteins. Does not contain melanocytes, Langerhans' cells, macrophages, lymphocytes, or tissue structures such as blood vessels, hair follicles, and sweat glands.

Wound Reference does not produce, market, re-sell or distribute health care goods or services consumed by, or used on, patients.

●	Composition: Animal-derived
●	Composition: Human dermis with/without epidermis
	Composition: Human placenta or umbilical cord
	Composition: Viable (living) cells
	Configuration: Fenestrated/ meshed
	Configuration: Flowable
●	Configuration: Sheet
●	May apply on full-thickness wounds
	May apply over exposed tendon/ bone/ muscle
	May apply over infected tissue
	Processing: Cryopreserved
	Processing: Decellularized or irradiated
	Processing: Dehydrated
●	Processing: Fresh (limited shelf life)
	Processing: Hydrated
	Processing: Minimally manipulated
	Shelf life: Greater than 2 years
	Storage: refrigeration needed
	Storage: room temp

Compare Features

The addition of Skin Substitutes or Cellular or Tissue Based Products (CTPs) to certain wounds may afford a healing advantage over dressings and conservative treatments when these options appear insufficient to affect complete healing, after at least a 30 day period of comprehensive conservative therapy. There are currently a wide variety of bioengineered products available for soft tissue coverage to affect closure. • Human skin allografts are derived from donated human skin (cadavers) • Allogeneic matrices are derived from human tissue (fibroblasts or membrane) • Composite matrices are derived from human keratinocytes, fibroblasts and xenogeneic collagen • Acellular matrices are derived from xenogeneic collagen or tissue

For Medicare to cover this product, it needs to be ordered and applied by your clinician. A patient cannot purchase it directly from a Durable Medical Equipment (DME) store and receive reimbursement for it.

Go to Apligraf®

Apligraf®, Skin Substitute Per Square Centimeter

Other related brands: SkinTE, per square centimeter,

* Wound Reference does not produce, market, re-sell or distribute health care goods or services consumed by, or used on, patients.
** We do not accept paid advertising to guarantee unbiased product information

Important Notice: The product information contained on this page, including the product images and additional product materials, was collected from various supplier sources. All product claims and specifications are those of the product suppliers. Every effort has been made to ensure the accuracy of the product information, however on occasion manufacturers may alter their products or packaging without notice. Wound Reference assumes no liability for inaccuracies or misstatements about products. The properties of a product may change or be inaccurate following the posting or printing of the product information in the document, either in the print or online version. Due to product changes, information listed in this document is subject to change without notice. We recommend that you always read labels, warnings and instructions for use before using a product. Content on this site is for reference purposes and is not intended to be a substitute for professional advice given by a physician or other licensed healthcare professional.

Apligraf®, Skin Substitute Per Square Centimeter

Related Products (Compare Features )

Basic Navigation

Feature Navigation

Solutions

Individuals:

Institutions:

Special Features:

Newsletter Signup