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Hello,
Was wondering what your guideline was regarding treating a pt with a hx of Cisplatin chemotherapy for HBOT. Pt last dose was March of 2022. Thank you for any information
Jan 27, 2023 by Lisa Fischer, LVN
4 replies
Jeff Mize
RRT, CHT, UHMSADS
Lisa,
Thanks for your question. Here is a brief overview of Cisplatin and HBO. Cisplatin has been used for a number of years in a variety of cancer treatment protocols. The therapeutic benefit of this drug is realized through its ability to inhibit DNA synthesis affecting fibroblast production and collagen synthesis. Concomitant use of Cisplatin is a relative contraindication in patients who suffer from chronic, non-healing wounds and should not be considered for hyperbaric oxygen therapy due to diminished wound healing. In a life-threatening situation such as CAGE or gas gangrene, wound healing concerns are overridden by the emergency indication. I hope this helps.
Have a great day!
Jan 27, 2023
Thanks Jeff
Jan 27, 2023
David Charash
DO,CWS,FACEP,FUHM
Additional info on Cisplatin. To be clear, if a patient has completed their course of chemotherapy /cisplatin, then having the past history of cisplatin would not impair wound healing. If I had a patient that was on Cisplatin and was having a problem wound, a conversation with the prescribing Dr and patient whether to temporarily discontinue the Cisplatin. Of course it is always a risk benefit discussion. There should be no concern for a patient on Cisplatin requiring HBO treatment for a non wound indication.
Jan 27, 2023
Thank you for the info Dr Charash
Jan 30, 2023
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