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88, F, PMH of lymphedema, vascular disease, Hx of PE, Chronic embolism and thrombosis of other veins, long term Xarelto use, Lipoid dermato-arthritis, Hyperlipidemia, HTN, osteoarthritis. Patient has bilateral lower extremity ulcers and petechial rash (wondering if wound and rash are related). Arterial Duplex and wound biopsy were un remarkable. The larger wound is on left lower extremity & has been present since August, 2021. The smaller wound on the R lower extremity has been present for about a month (progressed very quickly). I took a PCR swab of the wound and treated her orally with Levaquin as the wounds were rapidly increasing in size, they had excessive drainage, and a foul odor. She is being treated topically with metrogel. The patient has previously tried dressing changes by home care nurse including use of mupirocin ointment, calcium alginate, Santyl, iodosorb, hydrofera blue ready, and foam dressings. Patient complains of bilateral lower extremity pain that is worse at night and relieved by walking (questioning if arterial doppler was incorrect). I plan to repeat arterial doppler and ABI. Patient doesn't tolerate wound cleanser or acetic acid as almost everything that touches her wounds causes extreme burning pain. She allowed me to complete debridement on the left leg ulcer, but it was extremely painful even with topical and injectable lidocaine. She will allow her wounds to be cleaned only with poured normal (she says the normal saline spray is painful). I have been treating her with ultramist 2x weekly for 3 weeks without improvement.

Medications: olmesartan-hydrochlorothiazide, ropinirole, Xarelto, allopurinol, clopidogrel, cholecalciferol (vitamin D3)
Her only new medications are Levaquin and metrogel. The rash was present prior to starting Levaquin and metrogel.
Feb 24, 2023 by Alicia Kohls,
4 replies
Cathy Milne
APRN, MSN, CWOCN-AP
My colleagues are free to chime in, of course, but this looks like an atypical wound..and acting like one,too. And yes, I think the rash is related..as is her history of repeated embolism…Have you considered a biopsy? Additionally, you’ll want to do some labs to help you narrow down what type of atypical wound it is.( e.g. neoplastic vs. vasculitic s. Inflammatory,etc.) Given her history, this may be a vasculopathic…so one good question to ask her is if she ever had a miscarriage. Check out WoundReference for specifics on the labs to order and for information on the biopsy procedure for the best, most reliable results…and use a dermatopathologist to read your tissue..a quick call to him/her when sending the tissue over goes along way in helping them to help you.
Let us know what you find out!
Cathy
Feb 24, 2023
Eugene Worth
MD, M.Ed., FABA, ABPM/UHM
I'm going out on a limb ... then cutting it off behind me.

A PubMed search revealed that there have been reported cases of Leukocytoclastic Vasculitis associated with Xarelto. I think that it fits both the clinical picture and the skin lesions.

I'll go back and crawl in my hole ...

Yes, the biopsy of some lesions and a dermatopathologist will solve this.
Feb 25, 2023
I believe the patient has had miscarriages since both of her children are adopted. I tried to call her to confirm this, but she did not answer her phone. The biopsy I did was unremarkable, but it sounds like I should try a dermatopathologist. Thank you
Feb 27, 2023
Eugene Worth
MD, M.Ed., FABA, ABPM/UHM
When you ask for the dermatopathologist review, be helpful and tell him/her that the patient takes Xarelto, and that your concern is Leukocytoclastic vasculitis. I have found derm path to always be helpful in this regard.
Feb 27, 2023
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