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Hi! I have an incoming patient with an oncologist planning to start Liposomal-doxorubicin. The oncologist advised it is a distant little cousin to the usual Doxorubicin. It is much milder and the side effects are not anything like Doxorubicins (per the oncologist), which is of course contraindicated with hyperbaric oxygen. Can you tell me if this therapy would be contraindicated for HBO as well? Thanks!
Feb 13, 2023 by Sarah Karson, RN, BSN
1 replies
Elaine Horibe Song
MD, PhD, MBA
Hi Sarah,
Discussed with Mike White MD and Tiff Hamm, BSN, RN:
The package insert for Liposomal-doxorubicin says that the difference in cardiac effects between traditional doxorubicin and iposomal-doxorubicin has not been studied and recommends that from the cardiac toxicity standpoint it be treated the same as traditional doxorubicin, with at least 3 days after the last dose.
See topic:
https://woundreference.com/app/topic?id=medications-in-the-hyperbaric-environment#doxorubicin-(adriamycin%C2%AE,-doxil%C2%AE,-rubex%C2%AE)
See package insert : https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/050718s029lbl.pdf
Feb 13, 2023
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