Mohammadi AA, Seyed Jafari SM, Kiasat M, Tavakkolian AR, Imani MT, Ayaz M, Tolide-ie HR, et al.
Burns : journal of the International Society for Burn Injuries. Date of publication 2013 Mar 1;volume 39(2):349-53.
1. Burns. 2013 Mar;39(2):349-53. doi: 10.1016/j.burns.2012.07.010. Epub 2012 Aug 27.
Effect of fresh human amniotic membrane dressing on graft take in patients with
chronic burn wounds compared with conventional methods.
Mohammadi AA(1), Seyed Jafari SM, Kiasat M, Tavakkolian AR, Imani MT, Ayaz M,
Tolide-ie HR.
Author information:
(1)Shiraz Burn Research Centre, Division of Plastic and Reconstructive Surgery,
Department of Surgery, Shiraz University of Medical Sciences, Iran.
mohamadiaa@sums.ac.ir
BACKGROUND: Burns are among the most devastating forms of injury. Nowadays the
standard treatment for deep partial thickness and full-thickness burn is early
excision and grafting, but this technique is not always feasible; and this leads
to chronicity and microbial colonization of burn wounds. Interesting properties
of human amniotic membrane made us use it in management of chronic infected burn
wounds.
METHODS: From January 2008 to September 2010, in a prospective clinical trail, 38
patients (76 limbs) with symmetric chronic burn wounds in both upper or lower
limbs included in this study. Tissue cultures were taken from all the wounds. For
the right, after debridement of granulation tissue and meshed split thickness
skin grafting, the graft surfaces were covered with amniotic membrane dressing
and in left limb wounds, after debridement, skin grafting was done in
conventional method. 21 days later, the success rate of graft take was compared
between two groups.
RESULTS: The study group was composed of 76 limbs in 38 patients with mean age of
27.18±6.38 and burn in 29.18±7.23 TBSA%. The most common causes of the burn
wounds chronicity in the selected patients was delayed admission due to poor
compliance of the patients (44.8%). Staphylococcus was the most frequent isolate
in wounds in our patients (62.85%). Mean graft take was observed in 90.13% of
right upper limbs, and 67.36% of left upper limbs; which was significantly
different (P<0.001).
CONCLUSIONS: Our study showed that human amniotic membrane dressing significantly
increases the success rate of graft take in chronic wounds, and it can be
recommended as an important dressing in chronic burn wounds management, due to
interesting anti-microbial, and better graft take effects.
Copyright © 2012 Elsevier Ltd and ISBI. All rights reserved.
DOI: 10.1016/j.burns.2012.07.010
PMID: 22951345 [Indexed for MEDLINE]
