Borda LJ, Wong LL, Marzano AV, Ortega-Loayza AG, et al.
Archives of dermatological research. Date of publication 2019 Mar 29;volume ():.
1. Arch Dermatol Res. 2019 Mar 29. doi: 10.1007/s00403-019-01912-1. [Epub ahead of
print]
Extracutaneous involvement of pyoderma gangrenosum.
Borda LJ(1), Wong LL(1), Marzano AV(2), Ortega-Loayza AG(3).
Author information:
(1)Department of Dermatology and Cutaneous Surgery, University of Miami Miller
School of Medicine, Miami, FL, USA.
(2)UOC Dermatologia, IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico,
Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università
degli Studi di Milano, Milan, Italy.
(3)Department of Dermatology and OHSU Wound and Hyperbaric Medicine, Oregon
Health and Science University, 3303 SW Bond Ave Center for Health and Healing
Building 1, Suite 16, Portland, OR, 97239, USA. ortegalo@ohsu.edu.
Pyoderma Gangrenosum (PG) is an inflammatory neutrophilic dermatosis (ND)
associated with underlying chronic inflammation and/or malignancy. Diagnosis
remains to be challenging as a gold standard diagnostic test is lacking. Initial
manifestations may include papules, vesicles, or pustules that subsequently
develop into ulceration with features of undermining and violaceous borders.
Timely recognition of pyoderma gangrenosum is impeded by clinical findings shared
with other etiologies, such as granulomatosis with polyangiitis, polyarteritis
nodosa, and antiphospholipid syndrome. As with any other ND, extracutaneous
involvement may also occur preceding, during, or following the appearance of skin
lesions. Sterile neutrophilic infiltrates have been found to affect internal
organs supporting the concept of PG being a systemic disease, with lung being the
most common extracutaneous manifestation followed by ocular and visceral
compromise. Therefore, in this review, we describe the current knowledge of
extracutaneous involvement of PG and its respective clinical manifestations to
aid dermatologists in diagnosis, management, and determining prognosis.
DOI: 10.1007/s00403-019-01912-1
PMID: 30923901
