Coleridge-Smith P, Lok C, Ramelet AA, et al.
European journal of vascular and endovascular surgery : the official journal of the European So.... Date of publication 2005 Aug 1;volume 30(2):198-208.
1. Eur J Vasc Endovasc Surg. 2005 Aug;30(2):198-208.
Venous leg ulcer: a meta-analysis of adjunctive therapy with micronized purified
flavonoid fraction.
Coleridge-Smith P(1), Lok C, Ramelet AA.
Author information:
(1)Department of Surgery, UCL Medical School, The Middlesex Hospital, London WIN
8AA, UK.
OBJECTIVE: To assess the effect of oral treatment with micronized purified
flavonoid fraction (MPFF) on leg ulcer healing.
DESIGN: Meta-analysis of randomised prospective studies using MPFF in addition to
conventional treatment.
MATERIALS AND METHODS: Five prospective, randomised, controlled studies in which
723 patients with venous ulcers were treated between 1996 and 2001 were
identified. Conventional treatment (compression and local care) in addition to
MPFF was compared to conventional treatment plus placebo in two studies (N =
309), or with conventional treatment alone in three studies (N = 414). The
primary end point was complete ulcer healing at 6 months.
RESULTS: At 6 months, the chance of healing ulcer was 32% better in patients
treated with adjunctive MPFF than in those managed by conventional therapy alone
(RRR: 32%; CI, 3-70%). This difference was present from month 2 (RRR: 44%; CI,
7-94%), and was associated with a shorter time to healing (16 versus 21 weeks; P
= 0.0034). The main benefit of MPFF was present in the subgroup of ulcers between
5 and 10 cm2 in area (RRR: 40%; CI, 6-87%), and those present for 6-12 months
duration (RRR: 44%; CI, 6-97%).
CONCLUSION: These results confirm that venous ulcer healing is accelerated by
MPFF treatment. MPFF might be a useful adjunct to conventional therapy in large
and long standing ulcers.
DOI: 10.1016/j.ejvs.2005.04.017
PMID: 15936227 [Indexed for MEDLINE]
